The dose-response for glycopyrrolate and heart rate in anesthetized children has not been define. We determined the dose-response for glycopyrrolate and heart rate in 50 chidren, ASA physical status 1 and 2, anesthetized with halothane and
nitrous
oxide.
Anesthesia was induced with 60~70% nitrous oxide of 4, 6, 8, 12 or 16μg·kg-1 was administered by rapid infusion to each subject. The effects of glycopyrrolate on heart rate, heart rhythm and systolic blood pressure were compared among dosage
groups,
and dose response curve for peak heart rate was constructed. Glycopyrrolate increased the heart rate in a dose-related manner upto 12μ·kg-1 except 16μg·kg-1 Fifty percent maximal response corresponded to 6.1μg·kg-1, and 95% maximal response
corresponded to 11.1μg·kg-1. None of the patients had nonsinus rhythm anfter glycopyrrolate injection. Except for glycopyrrolate given at 4μg·kg-1, the systolic blood pressure increased significantly after all other doses.
Glycopyrrolate in doses greater than or equal to 6μ·kg-1 increased the heart rate and systolic blood pressure children anesthetized with halothane and nitrous oxide.
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